Double Cone Blender for Pharmaceutical Powder Mixing
In pharmaceutical manufacturing, powder blending is a critical process that directly affects product quality, dosage accuracy, and regulatory compliance. Whether producing tablets, capsules, or granules, achieving a uniform distribution of active pharmaceutical ingredients (APIs) and excipients is essential. Improper mixing can lead to inconsistent potency, reduced efficacy, and increased waste.
Yinda YDW Series double cone mixer is widely recognized in the pharmaceutical industry for its ability to deliver gentle, uniform, and efficient mixing, making it ideal for delicate powders and granules.
What is a Double Cone Blender?
YDW Series double cone blender, also called a W-shaped mixer, is an industrial machine designed for uniform mixing of powders and granules. It consists of a W-shaped barrel, a feeding port, a discharge port, shift bearings, and an electrical control panel. The unique shape allows powders and granules to continuously tumble and roll inside the barrel, achieving thorough blending. Its polished stainless steel construction reduces adhesion, simplifies cleaning, and ensures compliance with GMP standards, which is crucial for pharmaceutical production.
YDW series Double Cone Mixer
https://www.youtube.com/watch?v=YjBv9hDYmlo
Why the Double Cone Blender is Ideal for Pharmaceutical Powder Mixing
In pharmaceutical powder processing, it is essential to maintain the original particle morphology and functional properties of active ingredients. The double cone blender utilizes a gentle tumbling motion during rotation, avoiding high shear forces that could cause particle breakage or structural alteration. This helps ensure that the formulation maintains stable flow characteristics and consistent dosage performance.
In addition, the double-cone chamber design, combined with a fully polished internal surface, allows powders to move freely during mixing and discharge smoothly after blending. This structural advantage allows the material to be released cleanly, preventing material retention inside the mixing chamber. For pharmaceutical manufacturing, this helps avoid batch-to-batch cross influence and supports strict GMP cleaning and changeover requirements.
How the Double Cone Blender Operates in Pharmaceutical Powder Mixing
During operation, the motor drives the double-cone shaped mixing barrel through a belt and reducer, enabling it to rotate smoothly. As the barrel turns, powders and granules inside are lifted and tumbled repeatedly, forming a gentle and continuous mixing action. This low-shear blending process protects fragile pharmaceutical ingredients and helps maintain particle integrity.
For powders with poor flowability or slight stickiness, an force agitator can be added to break up agglomerates and enhance overall mixing uniformity.
diagram of YDW Double Cone Blender
https://www.youtube.com/shorts/26h870gNOIA
Features of the Double Cone Blender for Pharmaceutical Powder Mixing
- Gentle&Low-Shear Mixing:The double-cone rotation allows powders and granules to tumble smoothly, protecting delicate or fragile ingredients from particle damage.
- High Mixing Uniformity:Typical mixing time ranges from 5–20 minutes, achieving stable mixing homogeneity required for pharmaceutical formulations.
- Optional ForceAgitator: For powders with poor flowability or slight stickiness, a force agitator can be installed to enhance internal movement and ensure consistent blending.
- Hygienic Construction:The mixing chamber is available in SS304 or SS316L, with full internal and external polishing to reduce powder adhesion and prevent contamination.
- Sanitary-Grade Discharge Valve:Equipped with a pharmaceutical-grade butterfly valve, enabling clean and controlled discharge without dust leakage.
- Dust-Proof Bearing Structure:The sealed bearing system prevents powder intrusion, extending service life and maintaining hygienic operation.
- Reliable Drive System:Uses a motor with belt-drive transmission, ensuring smooth rotation, low noise, and stable performance for continuous production.
- Supports Batch Production:Suitable for both small pilot batches and large-scale industrial manufacturing, making it flexible for various pharmaceutical processing needs.
Butterfly discharge valve
button control panel
force agitator
Applications in Pharmaceutical Powder Processing
The YDW Series double cone blender is suitable for a wide range of pharmaceutical powder operations:
- Tablet Formulation Blending
Homogenizes APIs and excipients before tablet compression to ensure uniform dosage and stable downstream performance. - Capsule Filling Preparation
Produces consistent, well-mixed powders and granules for accurate capsule dosing and reliable weight control during filling. - Botanical and Plant-Extract Powders
Handles plant-derived materials that are soft, fibrous, or shear-sensitive, preserving particle integrity while achieving uniform distribution. - Premixing with Micro-Dose Additives
Ensures precise and reproducible distribution of trace components, vitamins, or stabilizers throughout bulk powders. - Fragile or Heat-Sensitive Formulations
Maintains original particle morphology and prevents thermal or mechanical degradation through a low-shear tumbling action. - Laboratory, Pilot, and Full-Scale Production
Applicable to laboratory trials, pilot-scale testing, and full-scale manufacturing lines, offering predictable scale-up behavior and consistent batch reproducibility.
Yinda has extensive experience in pharmaceutical powder mixing, offering a wide range of models to meet different production capacities.We offer customized solutions and can supply complete production lines for pharmaceutical powder processing, including powder milling, mixing, and granulation.
If you are interested in our equipment or have similar production requirements, please contact us via the details below:
Contact Person: Dennie Yuan
Tel/ WeChat/WhatsApp: +86 13914192807
Email: dennie@yindamachinery.com
Website: www.yindamachinery.com